helixstreet.io is a Polkadot SDK chain and autonomous Google Cloud agent fleet that records what genomic and proteomic datasets exist, who owns them, who granted access, and what was computed against them — without putting the underlying sequences on chain.
Winner of Best Architectural Design in Google's All Things Agentic Hackathon (out of 12,260 participants) for Helixstreet — autonomous genomic fleet: a five-agent Gemini 3.5 Flash + Gemma 4 31B + DeepVariant pipeline with a hash-chained Firestore audit ledger and salted Merkle genome vault.
Each link between two datasets requires explicit cryptographic consent from both data owners and is finalized through on-chain governance on Polkadot coretime over XCM v5, while sequences remain inside HIPAA- and GDPR-bounded enclaves.
Track: The Fortified Enterprise Fleet. Drop a raw sequencing file (BAM) into a Cloud Storage bucket and walk away — no chat loop, no clicks, no waiting human. Eventarc wakes a governed five-agent fleet on Google ADK: a Gemma 4 31B intake gatekeeper screens with Model Armor and scrubs PII via Cloud DLP, Gemini 3.5 Flash dispatches Google DeepVariant on Cloud Batch, goes dormant across the compute gap, wakes itself when the VCF lands, cross-references 1000 Genomes in BigQuery and CPIC pharmacogenomics, and seals a tamper-evident digital twin in ~9 minutes.
helixstreet_intake (Gemma 4 31B) + 4 Gemini 3.5 Flash specialists with live OpenTelemetry / Cloud Trace spans.
CYP2C19 *2/*2 clopidogrel alert with Europe PMC citations.
COMMITMENT_ANCHORED) + SHA-256 audit chain verified on every refresh.
Nemotron-3 Nano 30B / Super 120B) and NVIDIA Clara Parabricks for multi-cloud sovereign deployments.
Complete proof of ownership for genomic data and relationships between datasets on an immutable ledger.
ZK circuits in the style of Icefish (IACR 2026/463) let you prove "my genotype meets the inclusion criteria" without revealing the genotype.
Connections validated by both data providers and approved through transparent on-chain governance.
Decentralized groups making drug development and safety rating more objective through collective intelligence.
Application-specific blockchain built for life sciences, supporting genomic and proteomic datasets natively.
Secured by Polkadot's shared validator set via coretime, with XCM v5 to compose with KILT identity, Crust storage and the wider ecosystem.
Ancestry data and links in the Helixstreet parathread can be utilized by other chains to create Clans in the Metaverse. Through Cross Consensus Messaging (XCM), Metaverse projects can integrate real-life data and relationships.
The Helixstreet Foundation is situated near Zug, the Swiss Crypto Valley, alongside the Cardano Foundation, Web3 Foundation, and the Ethereum Foundation.
The Future is Multi-Chain →A Polkadot validator and a public JSON-RPC endpoint, operated by the helixstreet team. No hidden infra, no third-party rentals.
1HMQVknF2rGz2vBegqA9jU4NhZKQtW7nZTDQykgeSm8FgPa
Polkadot's nominate flow does not accept a deep-link target — copy the stash above, then paste it into the dashboard's Favorites. Grade and performance numbers from turboflakes ONE-T.
wss://rpc-polkadot.helixstreet.io
wss://rpc-kusama.helixstreet.io
# chain name over HTTPS — one-liner sanity check curl -H "Content-Type: application/json" \ -d '{"id":1,"jsonrpc":"2.0","method":"system_chain","params":[]}' \ https://rpc-polkadot.helixstreet.io
Post inclusion criteria as a circuit. Participants submit an eligibility proof generated locally against their VCF. You learn who qualifies, not what their genome looks like.
Every access request, grant, and revocation is a signed extrinsic. If your data is used in a study, the consent receipt sits next to the result — you can revoke prospectively at any time.
Sequence-alignment proofs and verifiable GWAS pipelines anchor "this result was computed against this consented cohort with this method" to the chain. Useful for regulators, partners, and downstream IP NFTs.
Helixstreet doesn't reinvent identity, storage, or biotech-IP rails. It speaks XCM v5 to chains that already do those things well.
Listed peers are independent projects we compose with technically; this is not a statement of formal partnership.
Beyond the chain itself, helixstreet advises large pharmaceutical companies on where blockchain actually helps a life-sciences workflow — and, just as often, where it doesn't.
Consent and access audit trails, provenance of derived datasets, multi-party trial coordination, IP-NFT settlement, supply-chain attestations for biologics. Each one is a problem regulators already understand.
Putting raw genomes on chain. "Tokenize the patient." Anonymous DNA marketplaces. AI-on-genomes-on-chain combo plates. We will tell you no, in writing, with the references.
Scoped reviews, architecture workshops, and reference implementations on testnet. We work in writing, with citations, and against a defined exit criterion. Get in touch →
Helixstreet is Polkadot-native by design, but life sciences is a 20-year problem and the substrate matters less than the guarantees. These are the platforms we keep instrumented and benchmark against.
We benchmark consent-flow and proof-verification primitives against each of these on a rolling basis. When something there beats Polkadot for a specific life-science workload, we say so — and the advisory engagements above reflect that.
helixstreet.foundation/2 at A+ grade, public RPC endpoints for Polkadot and Kusama. Testnet: consent-receipt pallet, ZK eligibility-proof verifier. Roadmap: mainnet launch on Polkadot coretime, XCM bridges to KILT/Crust, federated-kinship coordinator. See the roadmap.How we built an event-driven, zero-chat-loop autonomous genomic fleet on Google ADK, Gemini 3.5 Flash, Gemma 4, and DeepVariant — and the five production bugs that shaped it.
Updated for Polkadot 2.0. What's actually involved in stitching consent, identity, storage and IP-settlement across chains via XCM v5 — with a concrete pseudo-XCM example.
Twins, theft, family leakage, irrevocability. The honest case against using genomes as a Sybil-resistance primitive, with the credible alternatives in zk-eligibility and HE-coordinated kinship.